Safety concerns over cell-derived pharmaceutical products being manufactured in supplements of fetal bovine serum (FBS) have lead to restrictions imposed by FDA and EMEA on the use of FBS.in cell cultures for human use, and replacing FBS whenever possible. All recent scientific literature recommend the use of human platelets lysates or releasates  as a substitute to FBS. An excellent article addressing this issue  is: Human platelet lysate: Replacing fetal bovine serum as a gold standard for human cell propagation? Burnouf et al,. (Biomaterials. 2016 Jan;76:371-87)

As such, XelyoMax is the most optimal substitute to FBS in the support of cell cultures for human use.